Celebrex® | Celebrex (Celecoxib) - 100mg (60 Capsules)

How does Celebrex (Celecoxib) work?

Celebrex capsules contain the active ingredient celecoxib, which is a type of medicine known as a non-steroidal anti-inflammatory drug (NSAID).

NSAIDs work by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in producing prostaglandins, in response to injury or certain diseases. These prostaglandins cause pain, swelling and inflammation. Because NSAIDs block the production of these prostaglandins, they are effective at relieving pain and inflammation.

Cyclo-oxygenase does not only produce prostaglandins that cause inflammation. It also produces prostaglandins that have useful roles in the body. There are two different forms of cyclo-oxygenase, COX-1 and COX-2. COX-2 is the form that (among other things) produces prostaglandins that cause inflammation. COX-1 does not produce inflammatory prostaglandins, but does produce others that have useful effects, including some that are involved in maintaining a healthy stomach and intestinal lining.

Traditional NSAIDs, such as ibuprofen or diclofenac, block the action of both COX-1 and COX-2, and this is why they can sometimes cause side effects such as stomach irritation and peptic ulcers. Celecoxib belongs to a new generation of NSAIDs that selectively block the action of COX-2. This means that it stops the production of inflammatory prostaglandins, without stopping the production of prostaglandins that protect the stomach and intestines. It therefore reduces pain and inflammation, but is less likely than traditional NSAIDs to cause side effects on the stomach and intestines (although such side effects are still possible).

What is Celebrex (Celecoxib) used for?

• Rheumatoid arthritis
• Osteoarthritis

Celebrex (Celecoxib) Side Effects

• Duffuculty in sleeping
• Inflammation of the sinuses
• Dizziness
• Inflammation of the throat
• Inflammation of the lining of the nose (rhinitis) causing a blocked or runny nose
• Disturbances of the gut such as indigestion, diarrhoea, constipation, nausea, vomiting, flatulence or abdominal pain.
• Retention of water in the body tissues (fluid retention)causing swelling, particularly of the legs and ankles (peripheral oedema).
• Skin reactions such as rash
• Blurred vision
• Tiredness
• Anxiety
• Depression
• Increased potassium level in the blood
• Pins and needles
• Sensation of ringing or other noise in the ears
• Shortness of breath
• High blood pressure
• Heart attack or stroke
• Ulceration or bleeding of the stomach or intestines
• Liver, kidney or blood disorders