Colgout® | Colgout (Colchicine) - 0.5mg (100 Tablets)
| Main Use |
Active Integredient |
Marketed Name |
| Gout |
Colchicine. |
Colgout®, Colchicine® (UK) |
How does Colgout (Colchicine) work?
Colchicine was originally extracted from the autumn crocus but is now synthesised. Colchicine binds to a substance (tubulin) found in white blood cells (leucocytes).
In gout, crystals of uric acid are deposited in certain joints. White blood cells migrate to the areas of the body where uric acid has been deposited. They attempt to engulf the crystals, and, as a result,lactic acid and pro-inflammatory enzymes are released. These substances give rise to the characteristic pain and swelling of gout.
Colchicine inhibits the migration of the white blood cells into the inflamed area, causing a reduction in pain and inflammation.
Colgout (Colchicine) used for?
- Acute gout
- Short-term prevention of gout
Colgout (Colchicine) Side effects
- Rash
- Diarrhoea
- Decreased production of blood cells by the bone marrow (bone marrow suppression)
- Bleeding from the stomach
- Damage to the liver
- Damage to the kidneys
- Abdominal pain
- Nausea and vomiting
- Blood disorders
- Disorder of the muscles (myopathy)
- Loss of hair
- "Pins and needles" sensation in hands and feet (peripheral neuritis)
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